Golgi Bodies
Final processing of proteins take place in Golgi bodies.
Lipid synthesis takes place in it.
The mannose-6-Phosphate tagging of N- linked glycosylated protein takes place in Golgi. This tagged glycoprotein is directed to lysosome only.
Sulphation of tyrosine residue of proteins takes place here.
Proteolytic cleavage of certain protein also takes place in it.
Golgi has glycerol based phospholipid (Phosphatidyl choline), the choline group is transferred to ceramides to form sphingiomyelin in Golgi.
The Golgi release carbohydrate during cell plate formation in cell division.
Lysosomes
These are single membrane organelle.
They consist of variety of hydrolytic enzymes and function at acidic pH.
The membrane on the inner side of lysosome has carbohydrate coating which protect it from enzymes present inside it.
Many membrane proteins function as H+ ATPase to pump H+ inside lysosome.
It contains different phosphatase, protease, peptidase, nuclease, lipase etc variety of enzymes for degradation of complex molecules.
When a cell engulf a foreign material by endocytosis it forms early endosomes(fused product of plasma membrane and trans golgi).
When more content is delivered from Golgi to early endosome it becomes late endosome.
The enzymes of endosomes are inactive as they require acidic environment for activation, the acidic environment can be achived by two mechanisms: 1. Late endosome fuse with already existing lysosome or 2. The lumen can be made acidic by H+ATPase pump activity.
Lysosome can be heterophagic: containing extracellular material or autophagic: containing own cell material.
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Final processing of proteins take place in Golgi bodies.
Lipid synthesis takes place in it.
The mannose-6-Phosphate tagging of N- linked glycosylated protein takes place in Golgi. This tagged glycoprotein is directed to lysosome only.
Sulphation of tyrosine residue of proteins takes place here.
Proteolytic cleavage of certain protein also takes place in it.
Golgi has glycerol based phospholipid (Phosphatidyl choline), the choline group is transferred to ceramides to form sphingiomyelin in Golgi.
The Golgi release carbohydrate during cell plate formation in cell division.
Lysosomes
These are single membrane organelle.
They consist of variety of hydrolytic enzymes and function at acidic pH.
The membrane on the inner side of lysosome has carbohydrate coating which protect it from enzymes present inside it.
Many membrane proteins function as H+ ATPase to pump H+ inside lysosome.
It contains different phosphatase, protease, peptidase, nuclease, lipase etc variety of enzymes for degradation of complex molecules.
When a cell engulf a foreign material by endocytosis it forms early endosomes(fused product of plasma membrane and trans golgi).
When more content is delivered from Golgi to early endosome it becomes late endosome.
The enzymes of endosomes are inactive as they require acidic environment for activation, the acidic environment can be achived by two mechanisms: 1. Late endosome fuse with already existing lysosome or 2. The lumen can be made acidic by H+ATPase pump activity.
Lysosome can be heterophagic: containing extracellular material or autophagic: containing own cell material.
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